Edecrin

Edecrin is a strong "water pill" (diuretic). Using too much of Edecrin can lead to serious water and mineral loss. Therefore, it is important that you be monitored by your doctor. Promptly notify your doctor if you become very thirsty, have a dry mouth, become confused, or develop muscle cramps/weakness.

            Edecrin is used for:

Treating swelling due to congestive heart failure, liver problems, and severe kidney problems. It may also be used for other conditions as determined by your doctor.

Edecrin is a loop diuretic. It works by making the kidneys eliminate larger amounts of electrolytes (especially sodium and potassium salts) and water than normal (diuretic effect). It is useful for treating many conditions in which salt and water retention (eg, edema, swelling) is a problem.

Do NOT use Edecrin if:

you are allergic to any ingredient in Edecrin or to sulfonamides

you are unable to urinate

you are taking an aminoglycoside antibiotic (eg, gentamicin) or cephalosporin (eg, cephalexin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Edecrin :

Some medical conditions may interact with Edecrin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have fluid in your abdomen, hearing problems, liver disease, diabetes, low urine output, high blood uric acid levels or gout, a blood disorder, kidney disease, lupus, heart problems or you have had a heart attack, or you are dehydrated

Some MEDICINES MAY INTERACT with Edecrin . Tell your health care provider if you are taking any other medicines, especially any of the following:

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) because the effectiveness of Edecrin may be decreased

Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), aminoglycosides (eg, gentamicin), cephalosporin (eg, cephalexin), or salicylates (eg, aspirin) because serious side effects to the kidneys (decreased ability to urinate) and ears (hearing loss) may occur

Chloral hydrate or corticosteroids (eg, prednisone) because the risk of side effects, such as excessive sweating, rapid heartbeat, stomach bleeding, and changes in blood pressure may be increased

Anticoagulants (eg, warfarin), digoxin, or lithium because the side effects may be increased by Edecrin

                      Use Edecrin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

Edecrin may be taken with or without food.

When you first start taking Edecrin , it may cause an increase in urine or in frequency of urination. If you are taking 1 dose daily, take it in the morning to prevent Edecrin from affecting your sleep. If you are taking more than 1 dose, take the last dose no later than 6 pm.

If you miss a dose of Edecrin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

              Edecrin may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Edecrin . Using Edecrin alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.

Edecrin may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.

Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.

Patients being treated for high blood pressure often feel tired or rundown for a few weeks after beginning therapy. Continue taking your medicine even though you might not feel quite "normal." Contact your health care provider or pharmacist about any new symptoms.

Patients being treated for high blood pressure should avoid using nonprescription medicines that contain stimulants, such as products used for dieting (appetite suppressants) or relieving cold symptoms (eg, pseudoephedrine).

Edecrin may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Edecrin . Use a sunscreen or protective clothing if you must be outside for a prolonged period.

Diabetes patients - Edecrin may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

LAB TESTS, including complete blood cell counts and blood pressure monitoring, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.

Use Edecrin with caution in the ELDERLY because they may be more sensitive to its effects.

Caution is advised when using Edecrin in CHILDREN because they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Edecrin during pregnancy. It is unknown if Edecrin is excreted in breast milk. Do not breast-feed while taking Edecrin .

Possible side effects of Edecrin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; lightheadedness; loss of appetite; nausea; restlessness; tiredness or weakness; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; confusion; diarrhea; drowsiness; dry mouth; excessive urination; fever; hearing loss; loss of appetite; muscle pain/cramps/weakness; muscle spasm; rapid or irregular heartbeat; restlessness; ringing in the ears; seeing a yellow color; seizures; severe dizziness; sudden joint pain; unusual bleeding or bruising; unusual thirst; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

         Store Edecrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep in a tight, light-resistant container. Exposure to light may cause a slight discoloration. Do not take discolored tablets. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Edecrin out of the reach of children and away from pets.

Dalteparin

Tell your doctor you use Dalteparin before you have any type of spinal puncture or epidural/spinal anesthesia. Patients who have these procedures while they use Dalteparin are at risk of developing a blood clot on or near the spinal cord. This could result in long-term or permanent paralysis.

The risk is increased in patients who have an indwelling epidural catheter, traumatic or repeated epidural or spinal puncture, a history of a deformed spine or spinal surgery, and in patients who use medicines that may affect blood clotting such as warfarin, aspirin, platelet inhibitors (eg, clopidogrel), and nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen).

If you have a spinal puncture or epidural/spinal anesthesia while you use Dalteparin , tell your doctor immediately if you notice any signs or symptoms of nerve problems, such as numbness or tingling, muscle weakness, or paralysis.

           Dalteparin is used for:

Preventing blood clots in patients who have certain illnesses or who will be having certain types of surgeries. It is also used along with aspirin to prevent certain problems caused by heart attacks or unstable angina (chest pain). It is also used to reduce the recurrence of blood clots in certain cancer patients. It may also be used for other conditions as determined by your doctor.

Dalteparin is a low molecular weight heparin (LMWH). It works by blocking the formation of blood clots.

Do NOT use Dalteparin if:

you are allergic to any ingredient in Dalteparin

you are allergic to heparin, benzyl alcohol, or pork products

you have active severe high blood pressure, major bleeding, or a history of low platelets or bleeding problems due to the use of heparin

you are receiving Dalteparin for unstable chest pain or heart attack and will be receiving local anesthesia

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dalteparin :

Some medical conditions may interact with Dalteparin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney problems, liver problems, stomach or intestinal problems (eg, ulcers), stroke, or vision problems caused by diabetes or high blood pressure

if you have inflammation of the heart due to a bacterial infection, or severe, uncontrolled high blood pressure

if you have a bleeding disorder, a history of brain bleeding or blood conditions, or von Willebrand disease

if you have recently had or are scheduled to have brain, spine, or eye surgery, an epidural catheter, or a spinal puncture

if you are taking medicines that affect platelets (eg, aspirin, clopidogrel, ticlopidine)

Some MEDICINES MAY INTERACT with Dalteparin . Tell your health care provider if you are taking any other medicines, especially any of the following:

Activated protein C, anticoagulants (eg, warfarin), dextran, dipyridamole, direct factor XA inhibitors (eg, rivaroxaban), direct thrombin inhibitors (eg, dabigatran), injectable cephalosporins (eg, cephazolin), injectable penicillins (eg, ampicillin), NSAIDs (eg, ibuprofen, ketorolac, naproxen), platelet inhibitors (eg, clopidogrel, ticlopidine), salicylates (eg, aspirin), sulfinpyrazone, or thrombolytics (eg, streptokinase) because the risk of side Use Dalteparin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Dalteparin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Dalteparin at home, carefully follow the injection procedures taught to you by your health care provider.

Do not use Dalteparin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Dalteparin should be given while sitting or lying down.

Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle.

Dalteparin may be injected in a U-shape around the navel, the upper outer thigh, or the upper outer section of the buttock. The injection site should be changed daily. When injection around the navel or thigh is used, a fold of skin must be held by the thumb and forefinger while the injection is given. The entire needle should be injected at a 45- to 90-degree angle.

Fixed dose syringes - To ensure delivery of the full dose, do not expel the air bubble from the prefilled syringe before injection. Hold the syringe assembly by the open sides of the device. Remove the needle shield. Insert the needle into the injection area. Depress the plunger of the syringe while holding the finger flange until the entire dose remaining in the syringe has been given. The needle guard will not be activated unless the entire dose has been given. Remove the needle from the patient. Let go of the plunger and allow the syringe to move up inside the device until the entire needle is guarded. Discard the assembly in approved containers.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

If you miss a dose of Dalteparin , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Dalteparin .

Important safety information:

Dalteparin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Tell your doctor or dentist that you take Dalteparin before you receive any medical or dental care, emergency care, or surgery.

Before you begin taking any new prescription or nonprescription medicine, check the label to see if it has aspirin or ibuprofen in it. If it does or you are not sure, contact your doctor or pharmacist.

Some forms of Dalteparin contain benzyl alcohol. Do not use medicine with benzyl alcohol in NEWBORNS or INFANTS. It may cause serious and sometimes fatal side effects. If you have questions, check with your doctor or pharmacist.

If you have ever had an allergic reaction to benzyl alcohol, ask your doctor or pharmacist if your medicine has benzyl alcohol in it.

Dalteparin may affect certain lab tests, including liver enzyme tests. Be sure your doctor and lab personnel know you are using Dalteparin .

Lab tests, including complete blood cell counts (eg, platelet counts) and tests for blood in the stool, may be performed while you use Dalteparin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Dalteparin with caution in the ELDERLY; they may be more sensitive to its effects, especially bleeding.

Dalteparin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Dalteparin may contain the preservative benzyl alcohol, which can cause harm to the fetus. If you become pregnant, use a formulation without this preservative. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dalteparin while you are pregnant. Dalteparin is found in breast milk. If you are or will be breast-feeding while you are using Dalteparin , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Dalteparin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild bleeding, bruising, irritation, pain, redness, or swelling at the injection site.

                       Store Dalteparin at room temperature, between 66 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Dalteparin out of the reach of children and away from pets.       

               

Caffeine

Caffeine is used for:

Restoring mental alertness or wakefulness if you are experiencing fatigue or drowsiness. It may also be used for other conditions as determined by your doctor.

Caffeine is a central nervous system stimulant. It works by stimulating the brain.

Do NOT use Caffeine if:

·         you are allergic to any ingredient in Caffeine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Caffeine :

Some medical conditions may interact with Caffeine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

·         if you are pregnant, planning to become pregnant, or are breast-feeding

·         if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

·         if you have allergies to medicines, foods, or other substances

·         if you have anxiety, liver problems, insomnia (trouble sleeping), or heart disease

Some MEDICINES MAY INTERACT with Caffeine . Tell your health care provider if you are taking any other medicines, especially any of the following:

·         Quinolones (eg, ciprofloxacin) because side effects such as problems sleeping, nervousness, jitteriness, or anxiety may occur

·         Theophylline because its actions and side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Caffeine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

                          Use Caffeine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

·         Caffeine may be taken with or without food.

·         Do not exceed the recommended dose or take Caffeine on a regular basis without checking with your doctor. Exceeding the recommended dose or taking Caffeine regularly may be habit-forming.

·         If you miss a dose of Caffeine and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Caffeine .

Important safety information:

·         Caffeine may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Caffeine . Using Caffeine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

·         Avoid large amounts of caffeine-containing foods and beverages, such as coffee, tea, cocoa, cola drinks, and chocolate. This includes any medicines that contain caffeine.

·         Caffeine is not to be used as a substitute for sleep.

·         Diabetes patients - Caffeine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

·         Caffeine is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.

·         PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Caffeine , discuss with your doctor the benefits and risks of using Caffeine during pregnancy. It is unknown if Caffeine is excreted in breast milk. If you are or will be breast-feeding while you are using Caffeine , check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, some people develop a need to continue taking Caffeine . This is known as DEPENDENCE or addiction.

If you suddenly stop taking Caffeine , you may experience WITHDRAWAL symptoms including dizziness, headache, unusual tiredness, irritability, muscle tension, or nausea.

Possible side effects of Caffeine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; irritability; nausea; nervousness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; shakiness; trouble sleeping; vomiting.

                        Store Caffeine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Caffeine out of the reach of children and away from pets.
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