Zaditor

Zaditor Drops is used for:

Temporary prevention of itching of the eye due to allergies.

Zaditor Drops is an antihistamine and mast cell stabilizer. It works by blocking the release of chemicals from cells involved in allergic reactions.

Use Zaditor Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

* To use Zaditor Drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.

* To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.

* Zaditor Drops is only for the eye. Do not get it in your nose or mouth.

* Do not wear contact lenses if your eye is red.

* Do not use Zaditor Drops to treat irritation caused by contact lenses.

* Remove contact lenses before you use Zaditor Drops; soft contact lenses may be placed back in the eyes 10 minutes after use of Zaditor Drops if your eyes are not red.

* If you miss a dose of Zaditor Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zaditor Drops.

* Zaditor Drops may cause mild stinging when you first put it in your eye. Contact your doctor if the stinging continues.

* Do not use Zaditor Drops for future eye problems without first checking with your doctor.

* Zaditor Drops may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.

* Zaditor Drops should not be used in CHILDREN younger than 3 years old; safety and effectiveness in these children have not been confirmed.

* PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zaditor Drops while you are pregnant. It is not known if Zaditor Drops is found in breast milk. If you are or will be breast-feeding while you use Zaditor Drops, check with your doctor. Discuss any possible risks to your baby.

Store Zaditor Drops at 77 degrees F (25 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zaditor Drops out of the reach of children and away from pets.

* If you have any questions about Zaditor Drops, please talk with your doctor, pharmacist, or other health care provider.

* Zaditor Drops is to be used only by the patient for whom it is prescribed. Do not share it with other people.

* If your symptoms do not improve or if they become worse, check with your doctor.

EBASTINE- anti histamine

Ebastine is a second-generation antihistamine which undergoes transformation to its active metabolite, carebastine. Its antihistamine and anti allergic effects have been demonstrated in in vitro and in vivo studies, in addition to data obtained from clinical trials. Patients with allergic rhinitis or chronic idiopathic urticaria experienced significant improvement in their symptoms with ebastine 10 or 20 mg once daily. Some studies in patients with seasonal allergic rhinitis (SAR) have indicated trends towards greater efficacy with the 20 mg than the 10 mg dose, although only 1 study has shown statistically significant benefits. In comparative trials in patients with SAR, ebastine 10 mg was as effective as most other second-generation antihistamines, including astemizole, azelastine, cetirizine, loratadine and terfenadine. Ebastine 20 mg/day was significantly superior to loratadine 10 mg/day in patients with SAR according to effects on secondary efficacy variables in comparative studies; 1 study found significantly greater changes from baseline in mean total symptom score with ebastine 20 mg (-43 vs -36% with loratadine, p = 0.045). In patients with perennial allergic rhinitis, ebastine 10 or 20 mg daily was significantly more effective than loratadine in reducing total symptom scores from baseline 1 comparative study. There have been no reports of serious adverse cardiac effects during ebastine therapy. Increases in corrected QT interval have been observed during clinical trials; however, these have not been considered clinically significant and were generally of similar magnitude to those seen with loratadine. The normal diurnal variation in QTc interval and the problems associated in correcting for changes in heart rate also complicate assessment of this issue. The incidence of adverse events during ebastine treatment is not significantly greater than that observed with placebo or other second-generation antihistamines. Conclusions: Ebastine 10 mg daily is a well tolerated and effective treatment for allergic rhinitis and chronic idiopathic urticaria. At this dosage, it is as effective as the other second-generation antihistamines against which it has been compared. Ebastine 20 mg has similar tolerability to the 10 mg dose, and trends towards greater efficacy with the higher dose have been shown in some studies. Ebastine does not appear to be associated with any significant cardiac adverse events. Ebastine is a useful treatment option for patients with allergic rhinitis or chronic idiopathic urticaria.