May stimulate satiety center in brain, causing appetite suppression. Phentermine hydrochloride metabolism is hepatic; it is not significantly biotransformed. Store at controlled room temperature (59° to 86°F).
* Advise patient using 8 mg dose to take up to 3 times daily as prescribed, ½ hour before meals, and to take last dose several hours before bedtime.
* Advise patient using 15 to 37.5 mg dose as a single daily dose before, or 2 h after, breakfast. Advise patient to swallow tablet or capsule whole and to not crush or chew the tablet or capsule.
* Encourage patient to follow medically supervised weight reduction program. Emphasize that this medication will only work in conjunction with a caloric-restricted diet and exercise program.
* Advise patient that medication should be taken as prescribed and to not stop taking or change the dose unless advised to do so by health care provider.
* Explain that appetite suppressant effects are temporary and tolerance to medication and dependence can occur. Caution patient to not increase the dose in an effort to overcome the tolerance when it occurs.
* Remind patients with diabetes to monitor blood sugar more frequently while implementing dietary restrictions and to notify health care provider if significant changes in blood sugar occur.
* Caution patient that drug may impair the ability to drive or perform other tasks requiring mental alertness.
* Advise patient to notify health care provider immediately if the following symptoms occur: decreased exercise tolerance, dyspnea, swelling of the feet or ankles, fainting, chest pain, palpitations, nervousness, or dizziness.
* Advise patient to notify health care provider if experiencing any unusual or unexplained symptoms.
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